Why the study?
Does the combination of losartan and hydrochlorothiazide safely reduce blood pressure in hypertensive patients with mild to moderate renal impairment?
Population
58 patients across two studies: 14 with normal renal function and 12 with mild to moderate renal impairment…
Comparison
Losartan 50 mg/hydrochlorothiazide 12.5 mg for 7… vs Patients with normal renal function; no…
Design
Cohort
Follow-up
Up to 12 weeks
Authors
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Supports BP lowering with losartan-HCTZ in mild-moderate renal impairment; leaves open need for randomized confirmation.
Does the combination of losartan and hydrochlorothiazide safely reduce blood pressure in hypertensive patients with mild to moderate renal impairment?
The combination of losartan and hydrochlorothiazide is effective and well-tolerated for blood pressure reduction in hypertensive patients with mild to moderate renal impairment.
Dickson et al. (2003) studied this question.
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