Why the study?
Does losartan reduce blood pressure and alter prostaglandin synthesis in postmenopausal women with essential hypertension?
Population
16 postmenopausal women with essential hypertension, mean age 59 years, and diastolic blood pressures of 95…
Comparison
Losartan 50 mg daily during weeks 5 to 8. vs Placebo during weeks 1 to 4 and weeks 9 to 12.
Design
Other, single-blind
Follow-up
12 weeks
Authors
Loading...
Supports losartan for BP reduction in postmenopausal hypertension; leaves open prostaglandin role pending larger trials.
Does losartan reduce blood pressure and alter prostaglandin synthesis in postmenopausal women with essential hypertension?
Losartan effectively lowers blood pressure in postmenopausal women with essential hypertension and low plasma renin activity without altering prostaglandin synthesis.
Smith et al. (1995) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: