September 17, 2003Nephrology Dialysis TransplantationOpen Access

There was a 7 +/- 2 mmHg fall in mean daytime systolic blood pressure and a 22 +/- 7% fall in protein/creatinine ratio at 4 weeks (both P < 0.05), with no significant difference between the 50 mg and 100 mg groups, and the changes were highly correlated (r = 0.64, P = 0.006).

View Full Paper

Ask AI

Bookmark

Why the study?

Does high-dose losartan (100 mg) reduce proteinuria more than standard-dose losartan (50 mg) via non-haemodynamic mechanisms in patients with non-diabetic chronic renal failure and hypertension?

Population

21 patients with proteinuria due to non-diabetic chronic renal failure and mild to moderate hypertension.

Comparison

Losartan 50 mg daily for 4 weeks, then 100 mg… vs Losartan 50 mg daily for 8 weeks

Design

RCT, randomized into two groups, single-blind

Follow-up

8 weeks

Authors

ACA Crowe

Discussion

Member takes

Overview

Dose escalation beyond 50 mg losartan unlikely to augment proteinuria reduction in non-diabetic CKD; confirms BP-lowering dependence.

Structured PICO

Does high-dose losartan (100 mg) reduce proteinuria more than standard-dose losartan (50 mg) via non-haemodynamic mechanisms in patients with non-diabetic chronic renal failure and hypertension?

Population

21 patients with proteinuria (>1 g/24 h) due to non-diabetic chronic renal failure (stable creatinine clearance >20 ml/min) and mild to moderate hypertension (130/80 < blood pressure < 160/110 mmHg).

Intervention

Losartan 50 mg daily for 4 weeks, then 100 mg daily for 4 weeks

Comparator

Losartan 50 mg daily for 8 weeks

Outcome

24-hour ambulatory blood pressure and renal parameters (protein/creatinine ratio, renal plasma flow, glomerular filtration rate, and filtration fraction) at 4 and 8 weekssurrogate

The antiproteinuric effect of losartan in non-diabetic chronic renal failure appears to be entirely dependent on its systemic blood pressure-lowering effect, with no additional benefit from higher doses.

Cite This Study

A Crowe (2003) studied this question.

synapsesocial.com/papers/6a89cd28273d243e4992ecf8 https://doi.org/10.1093/ndt/gfg315

View Full Paper

Ask AI

Bookmark

September 17, 2003Nephrology Dialysis TransplantationOpen Access

There was a 7 +/- 2 mmHg fall in mean daytime systolic blood pressure and a 22 +/- 7% fall in protein/creatinine ratio at 4 weeks (both P < 0.05), with no significant difference between the 50 mg and 100 mg groups, and the changes were highly correlated (r = 0.64, P = 0.006).

View Full Paper

Ask AI

Bookmark

Why the study?

Does high-dose losartan (100 mg) reduce proteinuria more than standard-dose losartan (50 mg) via non-haemodynamic mechanisms in patients with non-diabetic chronic renal failure and hypertension?

Population

21 patients with proteinuria due to non-diabetic chronic renal failure and mild to moderate hypertension.

Comparison

Losartan 50 mg daily for 4 weeks, then 100 mg… vs Losartan 50 mg daily for 8 weeks

Design

RCT, randomized into two groups, single-blind

Follow-up

8 weeks

Authors

ACA Crowe

Discussion

Member takes

Overview

Dose escalation beyond 50 mg losartan unlikely to augment proteinuria reduction in non-diabetic CKD; confirms BP-lowering dependence.

Structured PICO

Does high-dose losartan (100 mg) reduce proteinuria more than standard-dose losartan (50 mg) via non-haemodynamic mechanisms in patients with non-diabetic chronic renal failure and hypertension?

Population

21 patients with proteinuria (>1 g/24 h) due to non-diabetic chronic renal failure (stable creatinine clearance >20 ml/min) and mild to moderate hypertension (130/80 < blood pressure < 160/110 mmHg).

Intervention

Losartan 50 mg daily for 4 weeks, then 100 mg daily for 4 weeks

Comparator

Losartan 50 mg daily for 8 weeks

Outcome

24-hour ambulatory blood pressure and renal parameters (protein/creatinine ratio, renal plasma flow, glomerular filtration rate, and filtration fraction) at 4 and 8 weekssurrogate

Cite This Study

A Crowe (2003) studied this question.

synapsesocial.com/papers/6a89cd28273d243e4992ecf8 https://doi.org/10.1093/ndt/gfg315

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark