January 1, 2002The Nephron journals/Nephron journals

16 patients (64%) had a >25% decrease in daily urinary protein excretion (mean decrease 57 +/- 17%, p < 0.05), and sitting systolic blood pressure decreased from 142 +/- 17 to 125 +/- 13 mm Hg (p < 0.05).

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Why the study?

Does losartan reduce urinary protein excretion and blood pressure in diabetic and nondiabetic patients with proteinuria?

Population

n=25 patients (11 diabetic and 14 nondiabetic) with a daily urinary protein excretion >500 mg

Design

Cohort

Follow-up

16 weeks

Authors

JLJyh‐Gang Leu CHChee-Ming Huang SKShang‐Jyh Kao

Discussion

Member takes

Overview

Losartan was associated with proteinuria and BP reductions in this cohort; leaves open renoprotective effects on hard endpoints pending randomized trials.

Structured PICO

Does losartan reduce urinary protein excretion and blood pressure in diabetic and nondiabetic patients with proteinuria?

Population

n=25 patients (11 diabetic and 14 nondiabetic) with a daily urinary protein excretion >500 mg

Intervention

Losartan 25 mg or 50 mg once daily as monotherapy (without diuretics or other antihypertensive agents) for 16 weeks

Outcome

Change in daily urinary protein excretion at 16 weekssurrogate

Losartan monotherapy effectively reduces proteinuria, blood pressure, and serum uric acid in both diabetic and nondiabetic patients.

Cite This Study

Leu et al. (2002) studied this question.

synapsesocial.com/papers/6a85c6cf02a1bc3ea31e767a https://doi.org/10.1159/000064294

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January 1, 2002The Nephron journals/Nephron journals

16 patients (64%) had a >25% decrease in daily urinary protein excretion (mean decrease 57 +/- 17%, p < 0.05), and sitting systolic blood pressure decreased from 142 +/- 17 to 125 +/- 13 mm Hg (p < 0.05).

View Full Paper

Ask AI

Bookmark

Why the study?

Does losartan reduce urinary protein excretion and blood pressure in diabetic and nondiabetic patients with proteinuria?

Population

n=25 patients (11 diabetic and 14 nondiabetic) with a daily urinary protein excretion >500 mg

Design

Cohort

Follow-up

16 weeks

Authors

JLJyh‐Gang Leu CHChee-Ming Huang SKShang‐Jyh Kao

Discussion

Member takes

Overview

Losartan was associated with proteinuria and BP reductions in this cohort; leaves open renoprotective effects on hard endpoints pending randomized trials.

Structured PICO

Does losartan reduce urinary protein excretion and blood pressure in diabetic and nondiabetic patients with proteinuria?

Population

n=25 patients (11 diabetic and 14 nondiabetic) with a daily urinary protein excretion >500 mg

Intervention

Losartan 25 mg or 50 mg once daily as monotherapy (without diuretics or other antihypertensive agents) for 16 weeks

Outcome

Change in daily urinary protein excretion at 16 weekssurrogate

Losartan monotherapy effectively reduces proteinuria, blood pressure, and serum uric acid in both diabetic and nondiabetic patients.

Cite This Study

Leu et al. (2002) studied this question.

synapsesocial.com/papers/6a85c6cf02a1bc3ea31e767a https://doi.org/10.1159/000064294

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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