Key result
Diabetes was the most important predictor of recurrent MI or fatal CHD, with a multivariate-adjusted HR of 1.6 (95% CI 1.0-2.4) in men and 2.5 (95% CI 0.9-6.9) in women.
Why the study?
Do primary and secondary cardiovascular risk factors predict recurrent MI or fatal CHD in patients surviving a first MI?
Population
1635 patients (aged 45-70 years) surviving at least 28 days after a first MI
Comparison
Presence of primary and secondary cardiovascular… vs Absence or lower levels of these risk factors
Design
Cohort
Follow-up
6-9 years
Authors
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Diabetes may flag higher recurrence risk post-MI; leaves open whether targeting it improves outcomes in survivors.
Cohort (n=1,635)
Do primary and secondary cardiovascular risk factors predict recurrent MI or fatal CHD in patients surviving a first MI?
Effect estimate: HR 1.6 (95% CI 1.0-2.4)
Primary cardiovascular risk factors, particularly diabetes, significantly contribute to the long-term risk of recurrent MI or fatal CHD in post-MI survivors.
Leander et al. (2007) conducted a cohort in first myocardial infarction (n=1,635). Primary risk factors (e.g., diabetes) was evaluated on recurrent MI/fatal coronary heart disease (CHD) (HR 1.6, 95% CI 1.0-2.4). Diabetes was the most important predictor of recurrent MI or fatal CHD, with a multivariate-adjusted HR of 1.6 (95% CI 1.0-2.4) in men and 2.5 (95% CI 0.9-6.9) in women.
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