September 1, 1989American Journal of Epidemiology
Risk Factors for Long-Term Coronary Prognosis After Initial Myocardial Infarction: The Framingham Study
Why the study?
Do standard coronary heart disease risk factors predict the long-term risk of recurrent coronary events in survivors of an initial myocardial infarction?
Population
459 subjects who experienced an initial myocardial infarction and returned for a baseline examination in the…
Design
Cohort
Follow-up
up to 32 years (mean = 9.7 years)
Authors
Discussion
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Implication
May warrant ongoing risk factor surveillance post-MI; leaves open whether modification improves long-term outcomes.
Key Points
- To investigate the role of standard coronary risk factors in predicting long-term outcomes in myocardial infarction survivors.
- 69 subjects followed for up to 32 years post-infarction with average follow-up of 9.7 years.
- Cox proportional hazards model used to evaluate associations with reinfarction and coronary death.
- Postinfarction risk factors analyzed included blood pressure, serum cholesterol, and diabetes.
- Systolic pressure, serum cholesterol, and diabetes independently predicted reinfarction.
- Higher blood sugar and blood pressure were strongly associated with coronary death.
- Women experienced half the risk of coronary death compared to men, indicating a potential survival advantage.
Structured PICO
Do standard coronary heart disease risk factors predict the long-term risk of recurrent coronary events in survivors of an initial myocardial infarction?
P
Population
459 subjects who experienced an initial myocardial infarction and returned for a baseline examination (from an initial group of 697 subjects) in the Framingham Study
O
Outcome
Incident reinfarction or coronary deathhard clinical
Standard risk factors, particularly systolic pressure, serum cholesterol, and diabetes, remain important determinants of long-term coronary prognosis in survivors of an initial myocardial infarction.
Cite This Study
WONG et al. (1989) studied this question.