Key result
Lifetime depression linked to higher midlife arterial stiffness, with ~29% mediated by metabolic syndrome.
Why the study?
Previous research has linked depression with arterial stiffness during midlife, but the extent to which this association is mediated by metabolic syndrome remained uninvestigated.
Is a lifetime history of depression associated with elevated arterial stiffness in midlife adults, and is this mediated by metabolic syndrome?
Population
124 445 participants aged 40 to 69 years from the UK Biobank without prior cardiovascular disease
Comparison
Lifetime history of depression vs no depression history, assessing mediation via metabolic syndrome
Design
Population-based retrospective cohort study
Authors
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Depression history associated with higher midlife arterial stiffness partly via metabolic syndrome; hypothesis-generating for cardiometabolic pathways pending prospective confirmation.
Cohort (n=124,445)
Is a lifetime history of depression associated with elevated arterial stiffness in midlife adults, and is this mediated by metabolic syndrome?
Effect estimate: β 0.25 (95% CI 0.17-0.32)
A lifetime history of depression is associated with increased arterial stiffness in midlife, with approximately one-third of this effect mediated by metabolic syndrome and inflammation.
Dregan et al. (2020) conducted a cohort in Depression and Arterial Stiffness (n=124,445). Lifetime history of depression vs. No history of depression was evaluated on Peripherally assessed arterial stiffness index (ASI) (β 0.25, 95% CI 0.17-0.32). A lifetime history of depression was significantly associated with elevated midlife arterial stiffness index (β 0.25; 95% CI 0.17-0.32), with 29% of the association mediated by metabolic syndrome.
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