Key result
Chronic heart failure patients cluster into distinct cognitive profiles, with ~71% exhibiting cognitive deficits.
Why the study?
Cognitive impairment is a major comorbidity in chronic heart failure presenting with a wide range of phenotypes, prompting the identification and comparison of distinct cognitive deficit clusters.
Cohort (n=147)
No
Identifies distinct cognitive impairment profiles in chronic heart failure, highlighting that women and patients with prior valve surgery are at higher risk for global cognitive deficits.
May refine cognitive risk stratification in HF; leaves open whether profile-specific interventions improve outcomes.
Background: Cognitive impairment is a major comorbidity in patients with chronic heart failure (HF) with a wide range of phenotypes. In this study, we aimed to identify and compare different clusters of cognitive deficits. Methods: The prospective cohort study "Cognition.Matters-HF" recruited 147 chronic HF patients (aged 64.5 ± 10.8 years; 16.2% female) of any etiology. All patients underwent extensive neuropsychological testing. We performed a hierarchical cluster analysis of the cognitive domains, such as intensity of attention, visual/verbal memory, and executive function. Generated clusters were compared exploratively with respect to the results of cardiological, neurological, and neuroradiological examinations without correction for multiple testing. Results: = 0.048). Conclusion: Apart from cognitively healthy and globally impaired HF patients, we identified a group with deficits only in the intensity of attention. Women and patients with previous cardiac valve surgery are at risk for global cognitive impairment when suffering HF and could benefit from special multimodal treatment addressing the psychosocial condition.
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Göpfert et al. (2023) conducted a cohort in Chronic heart failure (n=147). Neuropsychological testing and cluster analysis was evaluated on Identification of cognitive profiles via hierarchical cluster analysis. Cluster analysis of chronic heart failure patients identified three distinct cognitive profiles: no deficits (28.6%), isolated attention deficits (37.4%), and global cognitive deficits (34.0%).
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