What question did this study set out to answer?

The aim is to evaluate the prognostic significance of NT-Pro BNP and CRP in patients with frequent VPC but no heart disease.

November 1, 2006Pacing and Clinical Electrophysiology

Increased Ventricular Ectopic Activity in Relation to C‐Reactive Protein, and NT‐Pro‐Brain Natriuretic Peptide in Subjects With No Apparent Heart Disease

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Why the study?

Does elevated C-reactive protein predict increased risk of death and acute myocardial infarction in healthy subjects with frequent ventricular premature complexes?

Population

678 healthy subjects between 55 and 75 years of age with no history of cardiovascular disease.

Comparison

Frequent ventricular premature complexes and… vs Subjects without frequent VPCs

Design

Cohort

Authors

ASAhmad SajadiehElectrophysiology ONOlav Wendelboe NielsenHeart Failure & Transplant VRVerner RasmussenHvidovre Hospital

Discussion

Member takes

Implication

May aid risk stratification among frequent VPCs; leaves open prospective validation and therapeutic implications.

Key Points

The aim is to evaluate the prognostic significance of NT-Pro BNP and CRP in patients with frequent VPC but no heart disease.
Included 678 healthy individuals aged 55 to 75 with no cardiovascular history.
Conducted fasting laboratory tests and 48-hour ambulatory ECG monitoring.
Defined frequent VPC as > or =30/hour and analyzed associations with biomarkers.
In subjects with frequent VPC (8% of the sample), those with elevated CRP had a significantly higher risk of poor prognosis (HR 3.6, 95% CI 1.8-7.1, P=0.0004).
Overall prognosis in participants with frequent VPC was poorer compared to those without (HR 2.3, 95% CI 1.2-4.4, P=0.01).
CRP above 2.5 microg/mL was the only tested biomarker associated with worse outcomes.

Structured PICO

Does elevated C-reactive protein predict increased risk of death and acute myocardial infarction in healthy subjects with frequent ventricular premature complexes?

Population

678 healthy subjects between 55 and 75 years of age with no history of cardiovascular disease.

Intervention

Frequent ventricular premature complexes (VPC ≥30/hour) and elevated C-reactive protein (≥2.5 µg/mL)

Comparator

Subjects without frequent VPCs

Outcome

Risk of death and acute myocardial infarctionhard clinical

In healthy middle-aged and elderly subjects with frequent ventricular premature complexes, elevated CRP (≥2.5 µg/mL) identifies a subgroup at significantly higher risk for death and acute myocardial infarction.

Cite This Study

Sajadieh et al. (2006) studied this question.

synapsesocial.com/papers/6a07b5e67ba19a189e06b338 https://doi.org/10.1111/j.1540-8159.2006.00518.x

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Increased Ventricular Ectopic Activity in Relation to C‐Reactive Protein, and NT‐Pro‐Brain Natriuretic Peptide in Subjects With No Apparent Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Increased Ventricular Ectopic Activity in Relation to C‐Reactive Protein, and NT‐Pro‐Brain Natriuretic Peptide in Subjects With No Apparent Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider