Why the study?
What is the prevalence of arrhythmias detected by 24 h ambulatory ECG in healthy volunteers?
What is the prevalence of arrhythmias detected by 24 h ambulatory ECG in healthy volunteers?
The high prevalence of baseline arrhythmias in healthy volunteers underscores the need for standardized guidelines to differentiate pre-existing abnormalities from drug-induced arrhythmias in early-phase clinical trials.
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High baseline arrhythmia rates in healthy volunteers warrant caution attributing ECG changes to drugs in trials; leaves open standardized reference norms for early-phase studies.
Stinson et al. (1995) studied this question.
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