What question did this study set out to answer?

To evaluate nebivolol's effects on left ventricular function in elderly heart failure patients with or without systolic dysfunction.

January 27, 2006European Heart JournalOpen Access

Effects of nebivolol in elderly heart failure patients with or without systolic left ventricular dysfunction: results of the SENIORS echocardiographic substudy

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To evaluate nebivolol's effects on left ventricular function in elderly heart failure patients with or without systolic dysfunction.
Randomized trial with 112 patients across 29 European centers
Patients stratified by ejection fraction (EF) <or=35% and EF>35%
Echocardiographic assessments of left ventricular parameters at baseline and 12 months
In patients with EF <=35%, nebivolol reduced end-systolic volume by 25.8 mL (95% CI: -46.6 to -5.0, P=0.016)
Increased ejection fraction by 4.6% (95% CI: 1.3 to 7.9, P=0.008) in the same group
No significant changes in EF >35% group or in diastolic parameters were observed.

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Supports nebivolol for LV remodeling in elderly HFrEF; extends beta-blocker evidence to this age group by EF.

Ghio et al. (2006) studied this question.

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