What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Orthostatic stress (n=13). Intervention: Modelflow vs. Echocardiography. Primary outcome: Stroke volume estimation across all timepoints (r = 0.56, p=<0.001).

What question did this study set out to answer?

This study aims to evaluate the accuracy of Modelflow in estimating stroke volume during orthostatic stress compared to echocardiography.

August 24, 2023Blood Pressure Monitoring

Evaluation of stroke volume estimation during orthostatic stress: the utility of Modelflow

Q: What are the key findings of this study?

Modelflow estimates of stroke volume during profound orthostatic stress were strongly correlated with echocardiography (r=0.56, P<0.001) and equivalent to within 15% of the clinical standard.

Q: What question did this study set out to answer?

This study aims to evaluate the accuracy of Modelflow in estimating stroke volume during orthostatic stress compared to echocardiography.

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Key result

Modelflow stroke volume estimates during orthostatic stress match echocardiography within ~15% equivalence.

r = 0.56
P<0.001
n=13

Why the study?

Modelflow non-invasively estimates beat-to-beat stroke volume, but its accuracy during profound reductions in stroke volume is unclear.

Does Modelflow accurately estimate stroke volume compared to echocardiography during orthostatic stress?

Population

13 individuals (age 24 ± 2 years; 7 female)

Comparison

Stroke volume estimation by Modelflow vs echocardiography

Design

Comparative physiological study

Authors

VLVera-Ellen M. LucciSimon Fraser University IPIain ParsonsKing's College London BHBrooke C. D. HockinSimon Fraser University

Discussion

Member takes

Implication

Modelflow may aid orthostatic SV research; leaves open larger validation before clinical adoption.

Key Points

This study aims to evaluate the accuracy of Modelflow in estimating stroke volume during orthostatic stress compared to echocardiography.
13 individuals tested using combined head-up tilt and graded lower body negative pressure until presyncope.
Stroke volume assessed via Modelflow and echocardiography while supine and during orthostatic stress.
Bland-Altman analyses and Two one-sided tests (TOST) used to assess bias and equivalency.
Modelflow estimates of stroke volume (73.2 ± 1.6 ml) are correlated with echocardiography estimates (66.1 ± 1.3 ml), P < 0.001.
TOST revealed equivalency to within 15% of echocardiographic estimates for stroke volume and SV index.
Bias improved when stroke volume was indexed to body surface area (+3.6 ± 12.0 ml.m -2).

Study Design

Type

Cross-Sectional (n=13)

Structured PICO

Does Modelflow accurately estimate stroke volume compared to echocardiography during orthostatic stress?

Population

13 individuals, age 24 ± 2 years, 7 female

Intervention

Modelflow (Finapres Medical Systems) non-invasive beat-to-beat stroke volume estimation during orthostatic stress (combined head-up tilt and graded lower body negative pressure until presyncope)

Comparator

Stroke volume estimation by echocardiography

Outcome

Accuracy of stroke volume estimation (bias, limits of agreement, and equivalency) at rest and during orthostatic challengesurrogate

Main Result

Effect estimate: r = 0.56

Absolute Event Rate: 73.2% vs 66.1%

p-value: p=<0.001

Modelflow provides accurate estimates of stroke volume during profound orthostatic stress compared to echocardiography, supporting its use in autonomic function testing.

Cite This Study

Lucci et al. (2023) conducted a cross-sectional in Orthostatic stress (n=13). Modelflow vs. Echocardiography was evaluated on Stroke volume estimation across all timepoints (r = 0.56, p=<0.001). Modelflow estimates of stroke volume during profound orthostatic stress were strongly correlated with echocardiography (r=0.56, P<0.001) and equivalent to within 15% of the clinical standard.

synapsesocial.com/papers/6a07b6537ba19a189e06b4f8 https://doi.org/10.1097/mbp.0000000000000671

Topics

Echocardiography

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Evaluation of stroke volume estimation during orthostatic stress: the utility of Modelflow

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Evaluation of stroke volume estimation during orthostatic stress: the utility of Modelflow

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

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Topics

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