Key result
Cognitive impairment in HF involves changes in the brain, systemic circulation, or both.
Why the study?
Heart failure and cognitive impairment are interlinked, but the underlying pathophysiological mechanisms have not been researched in depth in existing reviews.
Population
32 studies evaluating individuals with heart failure
Design
Systematic review
Authors
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Supports cognitive screening in heart failure; extends evidence for multifactorial brain and systemic mechanisms.
Systematic Review
Cognitive impairment in heart failure is driven by multiple pathophysiological mechanisms including brain structural changes, systemic inflammation, and altered hemodynamics, highlighting a bi-directional heart-brain relationship.
Ni et al. (2023) conducted a systematic review in Heart failure and cognitive impairment. Pathophysiological mechanisms of cognitive impairment in heart failure involve changes in the brain, systemic circulation, or both, based on a systematic review of 32 studies.
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