Key result
Moderate aerobic exercise reduces aortic calcification, chondrogenesis, and lipids in atherosclerotic rats.
Why the study?
To investigate the effects of aerobic exercise on aortic chondrogenesis and calcification, as well as 5-MTP/P38 MAPK signaling pathway expression, during atherosclerosis in rats.
Does aerobic exercise reduce aortic chondrogenesis and calcification in a rat model of atherosclerosis?
Does aerobic exercise reduce aortic chondrogenesis and calcification in a rat model of atherosclerosis?
Aerobic exercise reduces aortic chondrogenesis and calcification in atherosclerotic rats, potentially by increasing 5-MTP levels and inhibiting the P38MAPK/IL-6 signaling pathway.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating in rats; leaves open translation to human aortic calcification prevention.
BACKGROUND: 5-Methoxytryptophan (5-MTP), a new endothelial factor with vasoprotective and anti-inflammatory effects, reduces aortic chondrogenesis and calcification during atherosclerosis. The aim of this study was to investigate the effects of aerobic exercise on aortic chondrogenesis and calcification during atherosclerosis in rats. To investigate the effect of aerobic exercise on the expression of 5-MTP/P38 MAPK signaling pathway. To lay a theoretical foundation for the therapeutic effect of exercise in rat atherosclerosis model. METHODS: Establishment of a rat model of atherosclerosis using a high-fat diet combined with intraperitoneal injection of vitamin D3 (VD3). The aerobic exercise group underwent moderate-intensity aerobic exercise on an exercise treadmill for 8 weeks, while the atherosclerosis model group and the control group did not exercise. After exercise, blood and aortic samples were collected from all rats to evaluate the levels of serum triglyceride (TG), cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDLC), aortic chondrogenesis, calcification, 5-MTP level, collagen II, P38MAPK, pp38 MAPK, and IL-6 protein content. RESULTS: (1)8 weeks of aerobic exercise significantly reduced aortic chondrogenesis, area of calcification, serum LDL-C, TC levels, atherosclerotic index and serum IL-6 levels in rats (p < 0.01), and lowered TG levels (p < 0.05);(2)8 weeks of aerobic exercise significantly increased aortic 5-MTP levels (p < 0.01) and decreased the content of aortic pp38MAPK, collagen II and IL-6 proteins significantly (p < 0.01). The pp38MAPK/P38MAPK ratio was also decreased (p < 0.01). CONCLUSION: 8 weeks of aerobic exercise training improved dyslipidemia and reduced aortic chondrogenesis and calcification formation in AS rats. The mechanism may be related to increasing aortic 5-MTP levels and inhibiting the P38MAPK/ IL-6 signaling pathway.
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You et al. (2025) studied Atherosclerosis. Moderate-intensity aerobic exercise on a treadmill vs. No exercise (atherosclerosis model group and healthy control group) was evaluated on Aortic chondrogenesis and area of calcification (p=< 0.01). Eight weeks of moderate-intensity aerobic exercise reduced aortic chondrogenesis, calcification area, and lipid levels in atherosclerotic rats.
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