Effects of aerobic exercise on myocardial injury, NF-B expression, glucolipid metabolism and inflammatory factors in rats with coronary heart disease

Figures

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  Fig. 1. Evaluation the rat cardiac function. (A) LVEF%, (B) LVIDd, (C) LVFS%, (E) LVIDs. In contrast to control group and experimental group, LVEF% and LVFS% were lower, whereas the LVIDd and LVIDs were higher in model group. ⁎⁎p < 0.01 vs. control group, ## p < 0.01 vs. model group.

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  Fig. 2. HE staining to assay the morphological changes of rat myocardium. Scale bar = 500 μm.

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  Fig. 3. The cardiomyocyte apoptosis level in rats. (A) TUNEL staining chart. (B) Statistical chart of apoptotic cells. Scale bar = 50 μm. In contrast to control group and experimental group, cardiomyocyte apoptosis levels of model group were higher. ⁎⁎p < 0.01 vs. control group, ## p < 0.01 vs. model group.

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  Fig. 4. The glucose tolerance and blood lipid levels in rats. (A) FPG content. (B) LDL-C content. (C) HDL-C content. (D) TG content. (E) TC content. In contrast to control group and experimental group, the contents of FPG, LDL-C, TG and TC in model group were significantly increased, whereas HDL-C content was decreased. ⁎⁎p < 0.01 vs. control group, ##p < 0.01 vs. model group.

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  Fig. 5. Contents of inflammatory factors in rat myocardium. (A) TNF-. (B) IL-1. (C) IL-6. (D) IL-10. In contrast to control group and experimental group, TNF-, IL-6 and IL-1 contents were increased, whereas IL-10 content was decreased in model group. ⁎⁎p < 0.01 vs. control group, ## p < 0.01 vs. model group.

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  Fig. 6. Western blot to assay apoptotic protein expression in rat myocardium. (A) protein banding. (B) Caspase 3 expression. (C) Bcl-2/Bax. In contrast to control group and experimental group, Bcl-2/Bax protein expression in model group was decreased, while Caspase 3 protein expression was increased. ⁎⁎p < 0.01 vs. control group, ##p < 0.01 vs. model group.

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  Fig. 7. qPCR to assay mRNA expression in rat myocardium. (A) NF-B mRNA expression. (B) IB- mRNA expression. In contrast to control group and experimental group, NF-B mRNA expression in model group was increased, while IB- mRNA expression was decreased. ⁎⁎p < 0.01 vs. control group, ##p < 0.01 vs. model group.

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  Fig. 8. Western-blot to assay NF-B protein expression in rat myocardium. (A) protein banding. (B) NF-B expression. (C) IB- expression. (D) p-p38 expression. (E) p-STAT3 expression. In contrast to control group and experimental group, NF-B, p-p38 and p-STAT3 protein expressions in model group were increased, whereas IB- protein expression was reduced. ⁎⁎p < 0.01 vs. control group, ##p < 0.01 vs. model group.