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June 1, 2013ClinicsOpen Access

Aerobic exercise training reduced left ventricular end-diastolic pressure, left ventricular weight/body weight ratio, collagen volume fraction, and plasma levels of TNF-α and IL-6, while increasing IL-10 compared with the sedentary group.

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Why the study?

Does aerobic exercise training improve cardiac function, remodeling, and inflammatory profile in a rat model of chronic heart failure?

Population

29 Wistar rats subjected to myocardial infarction or sham surgery

Comparison

Aerobic training for 8 weeks vs Sedentary control (no exercise training)

Design

Preclinical

Follow-up

8 weeks

Authors

RNRamiro Barcos NunesJAJadson Pereira AlvesLKLuíza Pillar Kessler

Discussion

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Overview

Supports exercise in rat CHF model; leaves open clinical translation pending human trials.

Structured PICO

Does aerobic exercise training improve cardiac function, remodeling, and inflammatory profile in a rat model of chronic heart failure?

P
Population
29 Wistar rats subjected to myocardial infarction (chronic heart failure) or sham surgery (chronic heart failure trained n=7, chronic heart failure sedentary n=6, sham trained n=8, sham sedentary n=8)
I
Intervention
Aerobic training (treadmill running, 50 min/day, 5 times per week, 16 m/min) for 8 weeks
C
Comparator
Sedentary control (no exercise training)
O
Outcome
Cardiac functioning (hemodynamic variables), cardiac remodeling (left ventricular weight/body weight ratio, collagen volume fraction), and plasma levels of inflammatory cytokines (TNF-α, IL-6, IL-10)surrogate

Aerobic exercise training improves cardiac function, attenuates remodeling, and promotes a favorable inflammatory profile in a rat model of chronic heart failure.

Cite This Study

Nunes et al. (2013) studied this question.

synapsesocial.com/papers/6a73e3580375516f85f161d1https://doi.org/10.6061/clinics/2013(06)24
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Resistance Training Improves Hemodynamic Function, Collagen Deposition and Inflammatory Profiles: Experimental Model of Heart Failure2014 · 44 citations
  2. 2Endurance training in rats with chronic heart failure induced by myocardial infarction.1986 · 93 citations
  3. 3Exercise training prior to myocardial infarction attenuates cardiac deterioration and cardiomyocyte dysfunction in rats2013 · 32 citations
  4. 4Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction2002 · 246 citations
  5. 5Exercise Training in Chronic Heart Failure: Effects on Pro-Inflammatory Markers2004 · 87 citations