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October 23, 2014PLoS ONEOpen Access

Resistance Training Improves Hemodynamic Function, Collagen Deposition and Inflammatory Profiles: Experimental Model of Heart Failure

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Why the study?

Does an 8-week resistance training program improve hemodynamic function, collagen deposition, and inflammatory profiles in a rat model of chronic heart failure?

Population

32 male Wistar rats submitted to myocardial infarction by coronary artery ligation or sham surgery

Comparison

8-week resistance training program vs Sedentary chronic heart failure and sedentary…

Design

Preclinical

Follow-up

8 weeks

Authors

JAJadson Pereira AlvesRNRamiro Barcos NunesGSGiuseppe Potrick Stefani

Discussion

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Overview

Hypothesis-generating for resistance training in HF; leaves clinical translation open pending human trials.

Structured PICO

Does an 8-week resistance training program improve hemodynamic function, collagen deposition, and inflammatory profiles in a rat model of chronic heart failure?

P
Population
32 male Wistar rats submitted to myocardial infarction by coronary artery ligation or sham surgery
I
Intervention
8-week resistance training program (4 days/week, 4 sets of 10-12 repetitions/session, at 65% to 75% of one maximum repetition)
C
Comparator
Sedentary chronic heart failure (S-CHF) and sedentary sham (S-Sham) groups
O
Outcome
Hemodynamic function, maximum strength gain, collagen deposition, and inflammatory profilesurrogate

An 8-week resistance training program improves cardiac hemodynamics, reduces myocardial hypertrophy and fibrosis, and improves the inflammatory profile in a rat model of heart failure.

Cite This Study

Alves et al. (2014) studied this question.

synapsesocial.com/papers/6a1d554ecc9f7df1b70544a4https://doi.org/10.1371/journal.pone.0110317
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aerobic exercise improves the inflammatory profile correlated with cardiac remodeling and function in chronic heart failure rats2013 · 69 citations
  2. 2Resistance training alters skeletal muscle structure and function in human heart failure: effects at the tissue, cellular and molecular levels2011 · 74 citations
  3. 3Reduced collagen accumulation and augmented MMP-2 activity in left ventricle of old rats submitted to high-intensity resistance training2017 · 19 citations
  4. 4Resistance Training After Myocardial Infarction in Rats: Its Role on Cardiac and Autonomic Function2014 · 37 citations
  5. 5The effect of a period of detraining followed by resistance training on fibrosis, angiogenesis, and cardiac dimensions of male Wistar rats2024