Key result
Inotropes boost cardiac output in shock and HF but increase mortality via arrhythmia and ischemia.
Why the study?
Traditional inotropes increase cardiac output but are associated with excessive mortality from arrhythmia and myocardial ischemia, highlighting a pressing need for new inotropic agents that avoid these harmful effects.
This review highlights the need for novel inotropic agents that can improve cardiac output in heart failure and cardiogenic shock without the adverse effects of increased myocardial oxygen consumption and arrhythmias seen with older agents.
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Pressing need for safer inotropes in cardiogenic shock persists; leaves open whether novel agents can improve survival without excess arrhythmias.
Francis et al. (2014) conducted a review in Acute cardiogenic shock and heart failure. Inotropes was evaluated. Inotropes successfully increase cardiac output in acute cardiogenic shock and heart failure, but their use is limited by excessive mortality due to arrhythmia and myocardial ischemia.
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