Key result
Diabetic nephropathy linked to ~426% greater risk of subclinical LV systolic dysfunction in preserved LVEF.
Why the study?
What clinical features are associated with subclinical left ventricular systolic dysfunction (GLS < 18%) in asymptomatic patients with diabetes mellitus and preserved LVEF?
Cross-Sectional (n=144)
No
What clinical features are associated with subclinical left ventricular systolic dysfunction (GLS < 18%) in asymptomatic patients with diabetes mellitus and preserved LVEF?
Effect estimate: OR 5.26 (95% CI 2.111-13.12)
p-value: p=<0.001
Diabetic nephropathy, hypertriglyceridemia, and overweight/obesity are strongly associated with early-stage subclinical left ventricular systolic dysfunction (GLS < 18%) in asymptomatic patients with diabetes and preserved LVEF.
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May support GLS assessment in diabetic nephropathy; leaves open causal links and need for prospective trials.
Mochizuki et al. (2015) conducted a cross-sectional in Asymptomatic diabetes mellitus with preserved left ventricular ejection fraction (n=144). Diabetic nephropathy and other clinical risk factors vs. Absence of risk factors was evaluated on Subclinical left ventricular systolic dysfunction (Global Longitudinal Strain < 18%) (OR 5.26, 95% CI 2.111-13.12, p=<0.001). In asymptomatic patients with diabetes mellitus and preserved left ventricular ejection fraction, diabetic nephropathy was the strongest independent risk factor for subclinical left ventricular systolic dysfunction (OR 5.26).
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