Key result
Antihypertensive drug treatment reducing diastolic blood pressure by ~6 mm Hg reduced stroke risk by about 40% and CHD risk by about 10% (95% CI 0-20%).
Why the study?
Does antihypertensive drug treatment reduce the risk of stroke and coronary heart disease?
Does antihypertensive drug treatment reduce the risk of stroke and coronary heart disease?
Effect estimate: 10% reduction in CHD (95% CI 0-20)
Antihypertensive therapy rapidly achieves the full expected benefit for stroke reduction, but falls short of the expected benefit for coronary heart disease reduction within the first few years of treatment.
No takes yet. Share an insight, caveat, or question.
Supports prompt stroke protection with BP lowering; leaves open full CHD benefit accrual beyond 3 years.
MacMahon et al. (1989) conducted a review in Hypertension (n=450,000). Antihypertensive drug treatment vs. Control / Higher DBP was evaluated on Stroke and coronary heart disease (CHD) deaths and nonfatal myocardial infarctions (10% reduction in CHD, 95% CI 0-20). Antihypertensive drug treatment reducing diastolic blood pressure by ~6 mm Hg reduced stroke risk by about 40% and CHD risk by about 10% (95% CI 0-20%).
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