Key result
Sodium deprivation in dogs significantly increased renin activity in plasma, urine, and renal cortex (p<0.01), indicating urinary renin excretion correlates with plasma and renal renin activity.
Answers are grounded in this paper and cite their sources.
Caution against clinical extrapolation from canine data; leaves open validation of urinary renin as a human biomarker.
SummaryPlasma and urine renin activity were measured in dogs during control diet and sodium deprivation. Renin activity increased in both plasma (p < 0.01) and urine (p < 0.01) in parallel fashion during sodium deprivation and decreased with sodium replacement. In another group of dogs, sodium restriction had the same stimulatory effect on plasma (p < 0.01), urine (p < 0.01), and renal renin activity (p < 0.01). The results indicate that enhanced urinary excretion of renin is directly correlated to the increase in plasma and renal renin activity.
No takes yet. Share an insight, caveat, or question.
Hayduk et al. (1971) studied Sodium balance. Sodium deprivation vs. Control diet was evaluated on Renin activity in plasma, urine, and renal cortex (p=<0.01). Sodium deprivation in dogs significantly increased renin activity in plasma, urine, and renal cortex (p<0.01), indicating urinary renin excretion correlates with plasma and renal renin activity.
Synapse has enriched 10 related papers. Consider them for comparative context: