What question did this study set out to answer?

The study aims to explore the relationship between sudden death and glucose intolerance or diabetes in a specific population.

May 15, 1995Circulation

Sudden Death, Impaired Glucose Tolerance, and Diabetes in Japanese American Men

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Glucose intolerance and diabetes (n=8006). Intervention: High-normal glucose, asymptomatic high glucose, and diabetes vs. Lower glucose values (< 151 mg/dL). Primary outcome: Sudden death within 24 hours (RR 1.59, 2.22, 2.76, p=<= .05).

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Key result

Compared with lower glucose (<151 mg/dL), men with high-normal glucose, asymptomatic high glucose, and diabetes had increased relative risks for sudden death of 1.59, 2.22, and 2.76 (P<=0.05).

Why the study?

Does glucose intolerance or diabetes increase the risk of sudden death in Japanese American men?

Population

8,006 Japanese American men enrolled in the Honolulu Heart Program

Comparison

Glucose intolerance or history of diabetes vs Lower glucose values (< 151 mg/dL)

Design

Cohort

Follow-up

23 years

Authors

JCJ. David CurbBoston University BRBeatriz L. RodríguezBoston University CBCecil M. BurchfielCenters for Disease Control and Prevention

Discussion

Member takes

Implication

Glucose intolerance may signal higher sudden death risk in men; leaves open whether glucose control alters outcomes.

Key Points

The study aims to explore the relationship between sudden death and glucose intolerance or diabetes in a specific population.
Examined sudden death relation to glucose intolerance using 23 years of follow-up data.
Utilized nonfasting 1-hour postload measurements from 1965 for glucose assessment.
Adjusted for baseline factors including BMI, hypertension, and alcohol consumption.
Relative risks for sudden death within 24 hours were: 1.59 for high-normal, 2.22 for asymptomatic high glucose, and 2.76 for diabetes.
All relative risks were statistically significant (P ≤ .05).
The association between diabetes and sudden death was stronger for deaths classified as unknown causes.

Study Design

Type

Cohort (n=8,006)

Structured PICO

Does glucose intolerance or diabetes increase the risk of sudden death in Japanese American men?

Population

8,006 Japanese American men enrolled in the Honolulu Heart Program

Intervention

Glucose intolerance (measured by nonfasting 1-hour postload measurement: high-normal 151 to 224 mg/dL, asymptomatic high >= 225 mg/dL) or history of diabetes

Comparator

Lower glucose values (< 151 mg/dL)

Outcome

Sudden death, defined as unexpected death occurring within either 1 or 24 hours of first symptomshard clinical

Main Result

Effect estimate: RR 1.59, 2.22, 2.76

p-value: p=<= .05

Glucose intolerance and diagnosed diabetes are associated with a significantly increased risk of sudden death in Japanese American men over a 23-year follow-up.

Cite This Study

Curb et al. (1995) conducted a cohort in Glucose intolerance and diabetes (n=8,006). High-normal glucose, asymptomatic high glucose, and diabetes vs. Lower glucose values (< 151 mg/dL) was evaluated on Sudden death within 24 hours (RR 1.59, 2.22, 2.76, p=<= .05). Compared with lower glucose (<151 mg/dL), men with high-normal glucose, asymptomatic high glucose, and diabetes had increased relative risks for sudden death of 1.59, 2.22, and 2.76 (P<=0.05).

synapsesocial.com/papers/6a07f1fc09b3c820153789f8 https://doi.org/10.1161/01.cir.91.10.2591

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Sudden Death, Impaired Glucose Tolerance, and Diabetes in Japanese American Men

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Sudden Death, Impaired Glucose Tolerance, and Diabetes in Japanese American Men

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider