Key result
Following the publication of major clinical trials, the proportion of older adults initiating antihypertensive therapy on diuretics increased from 35.9% to 47.5%.
Why the study?
How did the patterns of antihypertensive medication use change among older adults between 1989 and 1992 in response to major clinical trials?
Population
Adults 65 years or older examined annually on four occasions between June 1989 and May 1992
Design
Cohort
Follow-up
3 years (June 1989 to May 1992)
Authors
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Increased diuretic initiation post-trials may shape current prescribing; leaves open outcome benefits in older adults.
Cohort
How did the patterns of antihypertensive medication use change among older adults between 1989 and 1992 in response to major clinical trials?
Absolute Event Rate: 47.5% vs 35.9%
Temporal trends in antihypertensive drug therapy between 1989 and 1992 showed an increased initiation and stabilization of diuretic use, coinciding with the publication of major clinical trials supporting low-dose diuretic therapy in older adults.
Bruce M. Psaty (1995) conducted a cohort in Hypertension. Antihypertensive medications was evaluated on Proportion initiating therapy on diuretics. Following the publication of major clinical trials, the proportion of older adults initiating antihypertensive therapy on diuretics increased from 35.9% to 47.5%.
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