The hypothesis that plasma chylomicrons and their remnants are atherogenic during the postprandial period in persons without familial hyperlipoproteinemia warrants further investigation.
Are postprandial chylomicron remnants atherogenic in individuals without familial hyperlipoproteinemia?
Highlights the potential role of postprandial chylomicron remnants in atherogenesis, suggesting a need for postprandial lipoprotein testing.
The hypothesis that plasma chylomicrons in persons who ingest a cholesterol-rich diet are atherogenic is evaluated. Evidence is presented that in humans, and experimental animals, chylomicron remnants as well as low-density lipoproteins are taken up by arterial cells. In persons who do not have familial hyperlipoproteinemia, atherogenesis may occur during the postprandial period. Research directions that may contribute to the evaluation of chylomicron remnants as a risk factor for atherogenesis are discussed. Lipoprotein studies after administration of a test meal containing fat and cholesterol are urgently needed.
D.B. Zilversmit (1979) conducted a review in Atherogenesis. Cholesterol-rich diet (postprandial state) was evaluated. The hypothesis that plasma chylomicrons and their remnants are atherogenic during the postprandial period in persons without familial hyperlipoproteinemia warrants further investigation.