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August 1, 1976Annals of the New York Academy of Sciences

Role of Triglyceride‐rich Lipoproteins in Atherogenesis*

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Key result

Chylomicron remnant accumulation in rabbits suggests cholesterol-rich lipoproteins are a product rather than precursor of atherogenesis.

Authors

DZD.B. ZilversmitCornell University

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Implication

Challenges traditional causality assumptions in atherogenesis; hypothesis-generating for human lipoprotein studies and requires prospective validation.

PICO

P
Population
Atherogenesis
E
Exposure / Comparator
Cholesterol feeding
O
Primary Outcome
Accumulation of cholesterol in atheromatous lesions

Cite This Study

D.B. Zilversmit (1976) studied Atherogenesis. Cholesterol feeding was evaluated on Accumulation of cholesterol in atheromatous lesions. Chylomicron remnant accumulation in cholesterol-fed rabbits suggests that plasma cholesterol-rich lipoproteins may be a product rather than a precursor of the atherogenic process.

synapsesocial.com/papers/6aa6cf0d50dab972bddd740ahttps://doi.org/10.1111/j.1749-6632.1976.tb43348.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Selective Measurement of Two Lipase Activities in Postheparin Plasma from Normal Subjects and Patients with Hyperlipoproteinemia1974 · 439 citations
  2. 2Lipoprotein Lipase Activity in Bovine Aorta1975 · 48 citations
  3. 3Myocardial infarction in young men. Study of risk factors in nine countries.1975 · 87 citations