Do gender differences in primary PCI mortality represent a different adherence to guideline recommended therapy? a multicenter observation
Key result
Female gender is not independently linked to higher in-hospital mortality after primary PCI for STEMI.
- n=1,104
Why the study?
Does female gender affect adherence to guideline-recommended therapy and mortality in patients undergoing primary PCI for STEMI?
Population
1,104 consecutive patients admitted with acute ST-elevation myocardial infarction and treated according to…
Comparison
Female gender vs Male gender
Design
Cohort
Follow-up
12 months
Authors
Discussion
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Member takes
Implication
Emphasizes improving adherence in women; supports risk-treatment paradox without implying causal gender effect.
Study Design
Type
Observational (n=1,104)
Multicenter
Yes
Structured PICO
Does female gender affect adherence to guideline-recommended therapy and mortality in patients undergoing primary PCI for STEMI?
P
Population
1,104 consecutive patients admitted with acute ST-elevation myocardial infarction (STEMI) and treated according to standardized protocols, approximately 25% female.
I
Intervention
Female gender (observational comparison of treatment and outcomes)
C
Comparator
Male gender
O
Outcome
In-hospital mortality and 12-month mortalityhard clinical
Main Result
Absolute Event Rate: 10% vs 5%
Higher unadjusted mortality in women after primary PCI for STEMI is driven by differences in baseline risk factors and lower guideline adherence (the risk-treatment paradox) rather than gender itself.
Cite This Study
Birkemeyer et al. (2014) conducted an observational in Acute ST-elevation myocardial infarction (STEMI) (n=1,104). Female gender vs. Male gender was evaluated on Unadjusted in-hospital mortality. Female gender was associated with higher unadjusted in-hospital mortality compared to males (10% vs 5%) after primary PCI for STEMI, but adjusted mortality did not differ significantly.