Key result
Obesity in HFpEF linked to ~21% lower exercising forearm blood flow versus nonobese patients.
Why the study?
Obesity is the primary comorbid condition in HFpEF pathophysiology, but the role of adiposity on the peripheral circulation is not well understood.
Does obesity impair exercising muscle blood flow and increase systemic inflammation in patients with HFpEF?
Observational (n=54)
Yes
Does obesity impair exercising muscle blood flow and increase systemic inflammation in patients with HFpEF?
Absolute Event Rate: 380% vs 484%
p-value: p=0.025
Obesity in HFpEF is associated with significantly impaired exercising skeletal muscle blood flow and heightened systemic inflammation, suggesting a distinct, more severe vascular phenotype.
Obesity may mark a severe HFpEF vascular phenotype; leaves open causal inflammation links and need for prospective trials.
Obesity is the primary comorbid condition in HFpEF pathophysiology, but the role of adiposity on the peripheral circulation is not well understood. The present study identified a 30%-40% reduction in forearm blood flow during handgrip exercise, accompanied by a marked elevation in proinflammatory plasma biomarkers, in obese patients with HFpEF compared with their nonobese counterparts. These findings suggest an exaggerated dysregulation in exercising muscle blood flow associated with the obese HFpEF phenotype.
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Ratchford et al. (2022) conducted an observational in Heart failure with preserved ejection fraction (HFpEF) (n=54). Obesity (BMI ≥ 30 kg/m2) vs. Nonobese (BMI < 30 kg/m2) was evaluated on Forearm blood flow at 45% maximal voluntary contraction (mL/min) (p=0.025). Obesity in patients with HFpEF significantly reduced exercising forearm blood flow across all work rates compared to nonobese patients (e.g., 380 vs 484 mL/min at 45% MVC).
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