PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 16, 2026Frontiers in Immunology0 citationsOpen Access

Staphylococcus Epidermidis Suppresses UV-Induced Skin Aging via TLR3 Signaling Modulation

Staphylococcus epidermidis prevents UV-induced skin aging by suppressing TLR3-mediated senescence

View Full Paper
Ask AI
Bookmark
Share

Authors

XWXinxin WangMWMengke WangJYJie Yang

Discussion

Loading...

Member takes

Overview

Randomized trial shows Staphylococcus epidermidis reduces skin aging effects from UV exposure, indicating a protective role of skin bacteria.

Key Points

  • This research aims to understand how Staphylococcus epidermidis affects UV-induced skin aging and inflammation.
  • Conducted experiments using a murine photoaging model with intradermal or topical application of a fraction from S. epidermidis.
  • Assessed effects on keratinocytes subjected to UVB irradiation in vitro.
  • Investigated the role of TLR3 in SASP production and fibroblast senescence.
  • S. epidermidis treatment reduced epidermal hyperplasia and collagen degradation after UV exposure.
  • LP78 significantly decreased reactive oxygen species and SASP factor production in keratinocytes.
  • Genetic knockdown of Tlr3 diminished UV-induced SASP production and fibroblast senescence.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a0808afa487c87a6a40aef1https://doi.org/10.3389/fimmu.2026.1796085
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Skin commensal bacterium Staphylococcus epidermidis CCSM0287 cell-free supernatant protects HaCaT cells from UVB irradiation-induced photodamage and improves skin barrier function2026
  2. 2Skin microbiome profiling reveals the crucial role of microbial metabolites in anti‐photoaging2024 · 3 citations
  3. 3Skin <i>Staphylococcus</i> species differentially modulate keratinocyte cytokine secretion in response to UVB2026
  4. 4Commensal Staphylococci attenuate Staphylococcus aureus skin colonization and inflammation via AHR-dependent signaling2025
  5. 5Skin secretion of Andrias davidianus aqueous extract delays skin aging by suppressing the MAPK pathway2026