May 1, 1991Hypertension
Relation of obesity and diet to sympathetic nervous system activity.
Key result
Increased body mass index and total caloric intake were independently associated with increased 24-hour urinary norepinephrine excretion (p=0.0001 and p=0.0055, respectively).
Why the study?
Are obesity and dietary intake associated with increased sympathetic nervous system activity in men?
Population
572 men aged 43-85 years from the Normative Aging Study
Comparison
Obesity and dietary intake vs Normal subjects
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports obesity and caloric intake as correlates of sympathetic activity in aging men; leaves open causality and clinical implications.
Study Design
Type
Cross-Sectional (n=572)
Structured PICO
Are obesity and dietary intake associated with increased sympathetic nervous system activity in men?
P
Population
572 men aged 43-85 years from the Normative Aging Study
I
Intervention
Obesity (measured by body mass index and abdomen-to-hip circumference ratio) and dietary intake (total caloric intake)
C
Comparator
Normal subjects (lower body mass index, lower caloric intake, normoglycemic/normoinsulinemic)
O
Outcome
Sympathetic nervous system activity assessed by measurement of 24-hour urinary norepinephrine excretionsurrogate
Main Result
p-value: p=0.0001
Obesity and higher caloric intake are independently associated with increased sympathetic nervous system activity, potentially mediated by insulin.
Cite This Study
Troisi et al. (1991) conducted a cross-sectional in Obesity and diet (n=572). Body mass index and total caloric intake vs. Lower BMI and caloric intake was evaluated on 24-hour urinary norepinephrine excretion (p=0.0001). Increased body mass index and total caloric intake were independently associated with increased 24-hour urinary norepinephrine excretion (p=0.0001 and p=0.0055, respectively).