January 30, 2001Zhongguo renshougonghuanbing zazhi
Hyperinsulinemia and Autonomic Nervous System Dysfunction in Obesity
Key result
Obesity and chronic hyperinsulinemia were associated with a 22% increase in cardiac output (P<0.03) and altered sympathovagal balance, which partially reversed with weight loss.
Why the study?
Is uncomplicated obesity with chronic hyperinsulinemia associated with autonomic nervous system dysfunction and altered hemodynamics compared to lean subjects?
Population
38 subjects, comprising 21 obese (body mass index, 35±1 kg/m2) and 17 lean subjects.
Comparison
Observational comparison of… vs Lean subjects.
Design
Cohort
Authors
Discussion
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Implication
May support weight loss to improve hemodynamics in obesity; leaves open causality of hyperinsulinemia pending prospective trials.
Study Design
Type
Observational (n=38)
Structured PICO
Is uncomplicated obesity with chronic hyperinsulinemia associated with autonomic nervous system dysfunction and altered hemodynamics compared to lean subjects?
P
Population
38 subjects (21 obese and 17 lean) evaluated for resting cardiac output, catecholamines, and heart rate variability, with a subset of 9 obese subjects re-evaluated after weight loss.
E
Exposure
Observational comparison of obesity/hyperinsulinemia; a subset of 9 obese subjects underwent 10% to 18% weight loss.
C
Comparator
Lean subjects.
O
Outcome
Resting cardiac output, plasma concentrations and timed urinary excretion of catecholamines, and 24-hour heart rate variability.surrogate
Main Result
Effect estimate: 22% increase
p-value: p=<0.03
Uncomplicated obesity with chronic hyperinsulinemia is associated with a high-output hemodynamic state and sympathetic dominance, which can be partially reversed by weight loss.
Cite This Study
Emdin et al. (2001) conducted an observational in Obesity (n=38). Obesity and chronic hyperinsulinemia vs. Lean subjects was evaluated on Cardiac output (22% increase, p=<0.03). Obesity and chronic hyperinsulinemia were associated with a 22% increase in cardiac output (P<0.03) and altered sympathovagal balance, which partially reversed with weight loss.