Key result
Physiological hyperinsulinemia increased the low-to-high frequency ratio in lean subjects (1.7 to 2.3, P<0.01) but not in obese subjects (2.4 to 2.2, P=ns), indicating altered autonomic balance.
Why the study?
Does physiological hyperinsulinemia alter autonomic control of cardiac function and hemodynamics in lean and obese humans?
Population
32 subjects, comprising 18 obese (BMI = 35 ± 1 kg/m2) and 14 lean (BMI = 24 ± 1 kg/m2) individuals.
Comparison
Physiological hyperinsulinemia via 1 mU/min/kg… vs Basal state (pre-insulin clamp).
Design
Other
Follow-up
2 hours
Authors
Loading...
May indicate blunted autonomic insulin responsiveness in obesity; hypothesis-generating and should not yet change practice.
Does physiological hyperinsulinemia alter autonomic control of cardiac function and hemodynamics in lean and obese humans?
p-value: p=<0.01
Physiological hyperinsulinemia induces a sympathetic shift and high-output hemodynamic state in lean individuals, whereas obese individuals exhibit these changes at baseline with blunted responsiveness to further insulin.
Elza Muscelli (1998) studied Obesity (n=32). Physiological hyperinsulinemia (insulin clamp) vs. Basal state was evaluated on Low-to-high frequency ratio (autonomic balance) (p=<0.01). Physiological hyperinsulinemia increased the low-to-high frequency ratio in lean subjects (1.7 to 2.3, P<0.01) but not in obese subjects (2.4 to 2.2, P=ns), indicating altered autonomic balance.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: