July 1, 2002Obesity ResearchOpen Access

Obesity Affects Myocardial Vasoreactivity and Coronary Flow Response to Insulin

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Why the study?

Does obesity alter myocardial vasoreactivity and coronary-flow response to insulin stimulation in men?

Structured PICO

Does obesity alter myocardial vasoreactivity and coronary-flow response to insulin stimulation in men?

Population

20 men, comprising 10 obese men (body mass index, 33.6 +/- 1.9 kg/m2) and 10 healthy matched non-obese men (body mass index, 24.2 +/- 1.9 kg/m2)

Intervention

Adenosine infusion (140 microg/kg per minute) with or without simultaneous physiological (1 mU/kg per minute) and supraphysiological (5 mU/kg per minute) hyperinsulinemia

Comparator

Healthy matched non-obese men

Outcome

Myocardial blood flow quantitated using positron emission tomography and oxygen-15-labeled watersurrogate

Young obese men exhibit reduced myocardial vasoreactivity and blunted insulin-induced enhancement of myocardial blood flow, indicating early endothelial dysfunction.

Discussion

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Implication

Suggests early endothelial dysfunction in obese men; hypothesis-generating for insulin's coronary effects, needs longitudinal validation.

Cite This Study

Sundell et al. (2002) studied this question.

synapsesocial.com/papers/6a70b9705671bbf00bc2c295 https://doi.org/10.1038/oby.2002.84

View Full Paper

Ask AI

Bookmark

Obesity Affects Myocardial Vasoreactivity and Coronary Flow Response to Insulin

Structured PICO

Discussion

Implication

Cite This Study

Obesity Affects Myocardial Vasoreactivity and Coronary Flow Response to Insulin

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider