Why the study?
Does physiological hyperinsulinemia alter autonomic control of cardiac function and hemodynamics in lean and obese humans?
Population
32 human subjects, comprising 18 obese (BMI 35 +/- 1 kg/m2) and 14 lean (BMI 24 +/- 1 kg/m2) individuals.
Comparison
Physiological hyperinsulinemia via 1… vs Basal state (pre-clamp).
Design
Other
Follow-up
2 hours
Authors
Loading...
Obesity may blunt further insulin effects on autonomic balance; hypothesis-generating for sympathetic contributions to cardiovascular risk.
Does physiological hyperinsulinemia alter autonomic control of cardiac function and hemodynamics in lean and obese humans?
Physiological hyperinsulinemia causes a sympathetic shift in autonomic balance and a high-output hemodynamic state in lean humans, changes that are already present at baseline in obese individuals.
Muscelli et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: