An elevated stress hyperglycemia ratio was significantly associated with increased odds of albuminuria in US adults with hypertension (OR 2.34; 95% CI 1.62-3.36; p < 0.001).
Cross-Sectional (n=8,732)
Yes
Is an elevated stress hyperglycemia ratio associated with an increased prevalence of albuminuria in adults with hypertension?
An elevated stress hyperglycemia ratio is independently associated with a higher prevalence of albuminuria in US adults with hypertension, highlighting its potential utility as a marker for early renal damage.
Effect estimate: OR 2.34 (95% CI 1.62-3.36)
p-value: p=<0.001
ABSTRACT The stress hyperglycemia ratio (SHR), a novel marker reflecting relative hyperglycemia, has been increasingly recognized for its prognostic value in cardiovascular and metabolic diseases. However, its association with early renal damage in hypertensive patients remains underexplored. This study aims to investigate the independent relationship between SHR and albuminuria in a nationally representative cohort of adults with hypertension. This cross‐sectional analysis included 8732 adults with hypertension from the National Health and Nutrition Examination Survey 2005–2018. Multivariable logistic regression models were used to evaluate the independent association between SHR and albuminuria, with adjustment for demographic, lifestyle, and clinical covariates. Restricted cubic splines (RCS) were employed to model nonlinear relationships. Stratified analyses were conducted across various subgroups. The prevalence of albuminuria was 15%. After full adjustment for confounders, compared to the reference quartile (Q2), the highest SHR quartile was significantly associated with an increased odds of albuminuria (OR: 2.34; 95% CI: 1.62–3.36; p 0.05). In this large, population‐based study, an elevated SHR is significantly and independently associated with a higher prevalence of albuminuria among US adults with hypertension.
Zhang et al. (Thu,) conducted a cross-sectional in Hypertension (n=8,732). Stress hyperglycemia ratio (SHR) vs. Reference quartile (Q2) was evaluated on Albuminuria (OR 2.34, 95% CI 1.62-3.36, p=<0.001). An elevated stress hyperglycemia ratio was significantly associated with increased odds of albuminuria in US adults with hypertension (OR 2.34; 95% CI 1.62-3.36; p < 0.001).