Key result
Higher stress hyperglycemia ratio links to ~90% higher odds of elevated BP in adolescents.
Why the study?
The stress hyperglycemia ratio has been associated with various diseases, but its relationship with elevated blood pressure in adolescents aged 12-17 remains unclear.
Is a higher stress hyperglycemia ratio (SHR) associated with an increased prevalence of elevated blood pressure in U.S. adolescents aged 12-17?
Cross-Sectional (n=3,676)
Is a higher stress hyperglycemia ratio (SHR) associated with an increased prevalence of elevated blood pressure in U.S. adolescents aged 12-17?
Higher stress hyperglycemia ratio (SHR) is independently associated with an increased prevalence of elevated blood pressure among U.S. adolescents, suggesting its potential utility as an early marker for cardiovascular risk.
No immediate clinical implications for adolescent BP management; leaves open whether SHR predicts future risk in prospective studies.
BACKGROUND: The stress hyperglycemia ratio (SHR) has been reported to be closely associated with various diseases and prognoses. However, the relationship between SHR and elevated blood pressure (EBP) in adolescents aged 12-17 remains unclear. METHODS: This cross-sectional study included U.S. adolescents from the 1999-2016 National Health and Nutrition Examination Survey (NHANES). The primary outcome was EBP. SHR was calculated by the formula [FPG (mmol/L)] / [1.59 × HbA1c (%) - 2.59]. Patients were divided into SHR quartiles. Weighted multivariable logistic regression models, subgroup analysis, restricted cubic spline (RCS) and receiver operating characteristic (ROC) curves, sensitivity analyses were used to evaluate the associations. RESULTS: A total of 3676 participants were included. Among them, 543 participants had EBP. In the fully adjusted model (Model 3), per SD increase in SHR was associated with a 17% higher odds of EBP (aOR 1.17, 95%CI 1.04-1.32, p = 0.009). Compared with the lowest quartile, participants in the highest quartile had a 95% higher odds of EBP (aOR 1.90, 95%CI 1.29-2.79, p for trend < 0.001). RCS analysis revealed a significant linear association between SHR and EBP (p for non-linearity > 0.05). ROC curves indicated that SHR had modest predictive performance for EBP in adolescents (AUC 0.723, 95%CI 0.699-0.747). CONCLUSIONS: This study suggests that higher SHR levels are positively associated with the prevalence of EBP among U.S. adolescents aged 12-17.
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Zheng et al. (2025) conducted a cross-sectional in Elevated blood pressure (n=3,676). Stress hyperglycemia ratio (SHR) vs. Lowest quartile of SHR was evaluated on Elevated blood pressure (EBP) (aOR 1.90, 95% CI 1.29-2.79, p=0.001). Higher stress hyperglycemia ratio levels were associated with a 95% higher odds of elevated blood pressure in the highest quartile compared to the lowest quartile among U.S. adolescents.
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