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This research investigates the impact of time of day and sex on renal responses to vasopressin receptor 2 modulation in mice.

May 16, 2026AJP Renal PhysiologyOpen Access

Diurnal and Sex-Specific Renal Responses to Vasopressin Receptor 2 Agonism and Antagonism in mice

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Randomized trial examines renal responses to vasopressin receptor 2 modulation in mice, suggesting time of day and sex affect treatment efficacy.

This research investigates the impact of time of day and sex on renal responses to vasopressin receptor 2 modulation in mice.
Adult male and female C57BL/6J mice received dDAVP injections at ZT5 or ZT17 after being placed on a high-water gel diet to suppress endogenous AVP.
Plasma osmolality and abundance of AQP2 phosphorylation were assessed one hour post-injection.
Urine flow was measured after administering the V2R antagonist tolvaptan at both ZT18 and ZT6.
dDAVP at ZT18 led to lower plasma osmolality and increased AQP2 phosphorylation compared to ZT6.
Urine flow peaked 2 hours post-tolvaptan injection, with male mice producing significantly more urine than females regardless of the time of day.

Nguyen et al. (2026) studied this question.

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Randomized trial examines renal responses to vasopressin receptor 2 modulation in mice, suggesting time of day and sex affect treatment efficacy.