April 24, 2013Nephrology Dialysis Transplantation

Long-term vasopressin-V2-receptor stimulation induces regulation of aquaporin 4 protein in renal inner medulla and cortex of Brattleboro rats

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Population

Brattleboro (BB) rats

Comparison

Desmopressin via osmotic minipumps for 6 days vs Saline (control) via osmotic minipumps

Design

Preclinical

Follow-up

6 days

Authors

SPSøren Brandt PoulsenAarhus University Hospital YKYoung‐Hee KimEwha Womans University JFJørgen FrøkiærCardiac Imaging

Discussion

Member takes

Implication

Hypothesis-generating for segment-specific AQP4 regulation by vasopressin; should not change clinical practice.

Structured PICO

Population

Brattleboro (BB) rats

Intervention

Desmopressin (dDAVP) via osmotic minipumps for 6 days

Comparator

Saline (control) via osmotic minipumps

Outcome

Aquaporin 4 (AQP4) protein abundance and immunolabelling in the renal inner medulla and cortexsurrogate

Long-term vasopressin-V2-receptor stimulation with dDAVP differentially regulates aquaporin 4 protein abundance across different segments of the renal collecting duct in Brattleboro rats.

Cite This Study

Poulsen et al. (2013) studied this question.

synapsesocial.com/papers/6a7ff7fd1024bacc96927d77 https://doi.org/10.1093/ndt/gft088

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Long-term vasopressin-V2-receptor stimulation induces regulation of aquaporin 4 protein in renal inner medulla and cortex of Brattleboro rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Long-term vasopressin-V2-receptor stimulation induces regulation of aquaporin 4 protein in renal inner medulla and cortex of Brattleboro rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider