Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 16, 2026Bioinformatics and Biology InsightsOpen Access

Integrated Analysis of lncRNA-miRNA-mRNA ceRNA Network and Identification of Hub lncRNAs in Molecular Subtypes of Gastric Cancer as Potential Prognostic Indicators

View Full Paper
Ask AI
Bookmark
Share

Authors

SGSeyed Navid GoftariFerdowsi University of MashhadABAhmad Reza BahramiFerdowsi University of MashhadMMMaryam Moghaddam MatinFerdowsi University of Mashhad

Discussion

Loading...

Member takes

Implication

Randomized trial identifies hub lncRNAs as potential prognostic indicators in gastric cancer subtypes, suggesting new pathways for treatment.

Key Points

  • This research aims to clarify the role of lncRNAs in different molecular subtypes of gastric cancer and predict patients’ overall relapse-free survival time.
  • Analyzed RNA-seq data from TCGA for lncRNAs, miRNAs, and mRNAs across gastric cancer subtypes and normal samples.
  • Constructed ceRNA networks using weighted gene co-expression network analysis (WGCNA) to identify co-expressing gene modules.
  • Performed survival analysis on identified hub lncRNAs across different gastric cancer subtypes.
  • Identified differential expression of lncRNAs, miRNAs, and mRNAs in each gastric cancer subtype, constructing specific ceRNA networks.
  • The top 5 lncRNAs with highest MCC scores were chosen as hub lncRNAs for each subtype.
  • Survival analysis indicated specific lncRNAs were associated with relapse-free survival in each molecular subtype.

Cite This Study

Goftari et al. (2026) studied this question.

synapsesocial.com/papers/6a080b17a487c87a6a40d27bhttps://doi.org/10.1177/11779322261433659
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Moderated estimation of fold change and dispersion for RNA-seq data with DESeq22014 · 104,982 citations
  2. 2Epidemiology of stomach cancer2022 · 511 citations
  3. 3Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology2022 · 1,775 citations
  4. 4Prognostic Autophagy-Related Model Revealed by Integrating Single-Cell RNA Sequencing Data and Bulk Gene Profiles in Gastric Cancer2022 · 12 citations
  5. 5HIP1R acts as a tumor suppressor in gastric cancer by promoting cancer cell apoptosis and inhibiting migration and invasion through modulating Akt2020 · 16 citations