Key result
Cardiomyopathy patients show ~33% higher LDH alongside elevated CRP, CK-MB, renal, and electrolyte biomarkers versus controls.
Why the study?
The study was aimed to investigate the level of physiological and biochemical parameters in cardiomyopathy patients.
Do biochemical parameters differ between patients with cardiomyopathy and healthy controls?
Case-Control (n=112)
No
Do biochemical parameters differ between patients with cardiomyopathy and healthy controls?
Cardiomyopathy patients exhibit significantly elevated levels of LDH, CRP, CK-MB, urea, potassium, and magnesium compared to healthy controls, reflecting ongoing myocardial damage and physiological alterations.
Answers are grounded in this paper and cite their sources.
Elevated biomarkers may reflect myocardial injury in cardiomyopathy; leaves open their diagnostic or prognostic utility pending prospective validation.
Cardiomyopathy is an affliction of the heart muscle that can result in heart failure.It comes in a variety of phenotypes, such as dilated, hypertrophic, and restricted. This study was aimed to investigate the level of physiological and biochemical parameters in Cardiomyopathy patients. Eighty two diagnosed cardiomyopathy adult patients with age range between (20-70) years, and thirty healthy with same range, were involved in this study during their attendance at Ibn Al-Bitar Center for Cardiac Surgery. The patients were diagnosed by an expert cardiologists based on ECG changes, Echocardiogram, chest x ray. The study was conducted from October 2020 to March 2021, and approved by ethical committees: Ref.: CSEC/0920/0052, September 15, 2020 of department of Biology, College of Science, University of Baghdad. Blood samples were collected the levels of biochemical parameters like troponin T, creatine kinase - MB (CK-MB), C-reactive protein (CRP), lactate dehydrogenase (LDH), Urea creatinine and electrolytes (Na+, Ca++, K+ and Mg+) were determined for the patients and control. The levels LDH, CRP) and CK-MB showed a highly significant (P<0.01) increase in patients compared with control, While the level of Troponin T showed non-significant (P≥ 0.05) differences.
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Mutlag et al. (2022) conducted a case-control in Cardiomyopathy (n=112). Cardiomyopathy vs. Healthy controls was evaluated on Lactate dehydrogenase (LDH) level (U/L) (p=0.0001). Cardiomyopathy patients exhibited significantly elevated levels of LDH, CRP, CK-MB, urea, creatinine, magnesium, and potassium compared to healthy controls.
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