Key result
Myocardial contrast echocardiography and velocity vector imaging identified early subclinical left ventricular dysfunction in sarcomere mutation carriers compared to 38 healthy controls.
Why the study?
Carriers of pathogenic sarcomere gene mutations without left ventricular hypertrophy remain at risk of progression to clinical HCM, prompting evaluation of myocardial perfusion and contractile function to identify early myocardial dysfunction.
Does multimodal ultrasound assessment (MCE and VVI) identify early myocardial dysfunction in familial HCM patients and their first-degree relatives compared to healthy controls?
Observational
Does multimodal ultrasound assessment (MCE and VVI) identify early myocardial dysfunction in familial HCM patients and their first-degree relatives compared to healthy controls?
MCE and VVI can quantitatively assess myocardial perfusion and function to detect early subclinical left ventricular dysfunction in sarcomere mutation carriers before the onset of hypertrophy.
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Yu et al. (2024) conducted an observational in Hypertrophic cardiomyopathy. Myocardial contrast echocardiography (MCE) and velocity vector imaging (VVI) vs. Gene-negative healthy family members was evaluated on Myocardial perfusion parameters (PI, TP, dI/dT) and strain parameters (GLS, GRS, GCS) (p=>0.05). Myocardial contrast echocardiography and velocity vector imaging identified early subclinical left ventricular dysfunction in sarcomere mutation carriers compared to 38 healthy controls.
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