Why the study?
Does cardiovascular magnetic resonance identify subtle functional and morphological abnormalities in hypertrophic cardiomyopathy mutation carriers with normal wall thickness compared to healthy controls?
Does cardiovascular magnetic resonance identify subtle functional and morphological abnormalities in hypertrophic cardiomyopathy mutation carriers with normal wall thickness compared to healthy controls?
Cardiovascular magnetic resonance can detect subtle functional and morphological abnormalities, including reduced circumferential strain and increased septal-to-lateral wall thickness ratio, in hypertrophic cardiomyopathy mutation carriers before the onset of overt hypertrophy.
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Supports CMR for preclinical detection in HCM carriers; leaves open whether changes predict progression or warrant intervention.
Germans et al. (2010) studied this question.
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