Key result
Doppler echocardiography demonstrated that isovolumetric relaxation time was significantly prolonged in patients with familial hypertrophic cardiomyopathy (105 vs 88 msec, P<0.001).
Why the study?
Can Doppler echocardiography identify structural and diastolic abnormalities in subjects with familial hypertrophic cardiomyopathy?
Population
346 subjects belonging to 20 unrelated families with familial hypertrophic cardiomyopathy, including 127…
Comparison
Doppler echocardiography vs Unaffected subjects
Design
Cross-sectional
Authors
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Supports diastolic assessment by Doppler in adult familial HCM; leaves open pediatric utility and requires prospective validation.
Observational (n=346)
Can Doppler echocardiography identify structural and diastolic abnormalities in subjects with familial hypertrophic cardiomyopathy?
Absolute Event Rate: 105% vs 88%
p-value: p=<0.001
Doppler echocardiography identifies prolonged isovolumetric relaxation time and altered diastolic filling in adults with familial hypertrophic cardiomyopathy, though standard echocardiographic criteria do not identify affected children.
Dubourg et al. (1995) conducted an observational in Familial hypertrophic cardiomyopathy (n=346). Doppler Echocardiography vs. Unaffected family members was evaluated on Doppler derived isovolumetric relaxation time (msec) (p=<0.001). Doppler echocardiography demonstrated that isovolumetric relaxation time was significantly prolonged in patients with familial hypertrophic cardiomyopathy (105 vs 88 msec, P<0.001).