Key result
Brugada syndrome and arrhythmogenic right ventricular cardiomyopathy share overlapping clinical and electrocardiographic features, suggesting that structural abnormalities may predispose to the Brugada pattern.
This review highlights the significant clinical and pathophysiological overlap between Brugada syndrome and ARVC, challenging the strict exclusion of structural heart disease in Brugada syndrome diagnostic criteria.
May warrant caution distinguishing Brugada from ARVC in overlapping cases; leaves open whether structural disease drives the phenotype pending prospective validation.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) and Brugada syndrome are distinct clinical entities which diagnostic criteria exclude their coexistence in individual patients. ARVC is a myocardial disorder characterized by fibro-fatty replacement of the myocardium and ventricular arrhythmias. In contrast, the Brugada syndrome has long been considered a functional cardiac disorder: no gross structural abnormalities can be identified in the majority of patients and its electrocardiographic hallmark of coved-type ST-segment elevation in right precordial leads is dynamic. Nonetheless, a remarkable overlap in clinical features has been demonstrated between these conditions. This review focuses on this overlap and discusses its potential causes and consequences.
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Mark G. Hoogendijk (2012) conducted a review in Brugada syndrome and arrhythmogenic right ventricular cardiomyopathy. Brugada syndrome and arrhythmogenic right ventricular cardiomyopathy share overlapping clinical and electrocardiographic features, suggesting that structural abnormalities may predispose to the Brugada pattern.
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