What is the clinical evidence from this study?

Study design: Cohort. Population: Chronic heart failure (n=270). Intervention: Hospitalisation vs. Pre-hospitalisation baseline. Primary outcome: Difference in EQ-5D index utility pre and post hospitalisation (Mean difference 0.020, 95% CI -0.020, 0.059).

August 3, 2020Health and Quality of Life OutcomesOpen Access

Impact of hospitalisation on health-related quality of life in patients with chronic heart failure

Q: What are the key findings of this study?

Nonfatal hospitalisation in patients with chronic heart failure was associated with a non-significant mean difference in EQ-5D index utility of 0.020 between pre- and post-hospitalisation measurements.

View Full Paper

Ask AI

Bookmark

Key result

Nonfatal hospitalization in chronic HF is not linked to significant changes in EQ-5D utility scores.

Mean difference 0.020
95% CI -0.020, 0.059
n=270

Why the study?

Empirical identification of the direct impact of hospitalisation on utility changes was needed to help interpret unexplained quality of life variance and inform economic evaluations.

Does nonfatal hospitalisation impact health-related quality of life in patients with chronic heart failure?

Population

Patients diagnosed with heart failure with utility records before and after hospitalisation

Comparison

Quality of life pre- vs post-hospitalisation

Design

Cohort study

Authors

FAFernando Albuquerque de AlmeidaPfizer (United States)MAMaiwenn AlErasmus University Rotterdam RKRon KoymansPhilips (Netherlands)

Discussion

Member takes

Implication

Nonfatal HF hospitalization was not linked to meaningful EQ-5D change; cohort data leave open cause-specific effects and need prospective validation.

Study Design

Type

Cohort (n=270)

Multicenter

Yes

Structured PICO

Does nonfatal hospitalisation impact health-related quality of life in patients with chronic heart failure?

Population

270 patients with chronic heart failure who experienced at least one hospitalisation (from a total cohort of 426), mean age 67.1 years, 19.6% women. Inclusion criteria: hospital admission due to or complicated by worsening heart failure lasting >48h within last 6 weeks, persisting symptoms, LVEF <40%, LV end-diastolic dimension >30 mm/m, medicated with furosemide ≥40 mg/day or equivalent, plus at least one indicator of further risk (unplanned CV admission >48h in previous 2 years, LVEF <25%, or furosemide ≥100 mg/day).

Intervention

Nonfatal hospitalisation (observational analysis of health-related quality of life before and after the event)

Outcome

Difference in utility measured using the EQ-5D-3L (index and visual analogue scale) before and after hospitalisationpatient reported

Main Result

Effect estimate: Mean difference 0.020 (95% CI -0.020, 0.059)

Hospitalisation in patients with chronic heart failure does not result in a significant overall change in health-related quality of life when measured before and after the event, though variations exist based on the primary cause of admission.

Limitations

The patient population was already in a very advanced stage of the disease.
Measurement of HRQoL was not done at a particular moment related to the hospitalisation, with large variances in time elapsed before and after.
Lack of information to adjust for other factors that might have affected changes in HRQoL, such as changes in medications or surgical procedures.
The EQ-5D-3L assesses global health status and may not be as responsive as a disease-specific instrument like the MLHFQ.

Cite This Study

Almeida et al. (2020) conducted a cohort in Chronic heart failure (n=270). Hospitalisation vs. Pre-hospitalisation baseline was evaluated on Difference in EQ-5D index utility pre and post hospitalisation (Mean difference 0.020, 95% CI -0.020, 0.059). Nonfatal hospitalisation in patients with chronic heart failure was associated with a non-significant mean difference in EQ-5D index utility of 0.020 between pre- and post-hospitalisation measurements.

synapsesocial.com/papers/6a082498df3db87398107deb https://doi.org/10.1186/s12955-020-01508-8

Topics

Heart failure hospitalization Heart failure HFrEF treatment

View Full Paper

Ask AI

Bookmark

Implication

Nonfatal HF hospitalization was not linked to meaningful EQ-5D change; cohort data leave open cause-specific effects and need prospective validation.

Impact of hospitalisation on health-related quality of life in patients with chronic heart failure

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Impact of hospitalisation on health-related quality of life in patients with chronic heart failure

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider