Key result
Treatment with rTGF-beta1 reduced myocardial necrosis and dysfunction (P<0.01) and inhibited MMP-1 upregulation (P<0.05) in rats subjected to ischemia-reperfusion injury.
p-value: p=<0.01
TGF-beta1 attenuates myocardial ischemia-reperfusion injury in rats, partly by inhibiting the upregulation of MMP-1, which directly causes myocyte injury.
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TGF-β1 may attenuate ischemia-reperfusion injury via MMP-1 in rats; leaves open human translation and therapeutic targeting.
Chen et al. (2003) studied Myocardial ischemia-reperfusion injury. Recombinant TGF-beta1 (rTGF-beta1) vs. Saline and sham I/R was evaluated on Myocardial necrosis, dysfunction, and MMP-1 upregulation (p=<0.01). Treatment with rTGF-beta1 reduced myocardial necrosis and dysfunction (P<0.01) and inhibited MMP-1 upregulation (P<0.05) in rats subjected to ischemia-reperfusion injury.
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