Key result
Warfarin therapy provides stroke prevention benefits that outweigh bleeding risks in octogenarians with atrial fibrillation, though targeting an INR below 2.0 increases stroke risk.
Why the study?
Does warfarin therapy prevent ischemic stroke in an 80-year-old man with atrial fibrillation and hypertension?
Does warfarin therapy prevent ischemic stroke in an 80-year-old man with atrial fibrillation and hypertension?
This case-based review provides practical guidance on initiating, monitoring, and managing warfarin therapy in elderly patients with atrial fibrillation.
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Supports warfarin consideration in octogenarians with AF if INR >2.0; leaves open need for dedicated elderly RCTs.
Gage et al. (2001) studied this question. Warfarin therapy provides stroke prevention benefits that outweigh bleeding risks in octogenarians with atrial fibrillation, though targeting an INR below 2.0 increases stroke risk.
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