Key result
Vitamin K therapy for critically high INR values (≥6.0) resulted in no difference in clinical outcomes compared to conservative management.
Why the study?
Does vitamin K therapy improve clinical outcomes compared to conservative management in outpatients with critically high INRs (≥6.0)?
Population
65 outpatients on oral anticoagulation with critical INRs and complete follow-up data, compared to an age…
Comparison
Vitamin K therapy vs Conservative management
Design
Cohort
Authors
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May support conservative management for outpatients with INRs ≥6.0; leaves open need for randomized confirmation.
Observational (n=65)
No
Does vitamin K therapy improve clinical outcomes compared to conservative management in outpatients with critically high INRs (≥6.0)?
Conservative management of critically high INR values (≥6.0) appears to be as efficacious as intervention with vitamin K therapy in outpatients.
Brigden et al. (1998) conducted an observational in Excessive oral anticoagulation (n=65). Vitamin K therapy vs. Conservative management was evaluated on Clinical outcome. Vitamin K therapy for critically high INR values (≥6.0) resulted in no difference in clinical outcomes compared to conservative management.
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