Key result
High-INR patients frequently had drug interactions or compliance issues; conservative management of INR ≥6.0 was as efficacious as vitamin K therapy with no difference in clinical outcomes.
Why the study?
Does vitamin K therapy improve clinical outcomes compared to conservative management in outpatients with critical INRs ≥ 6.0?
Population
65 outpatients on oral anticoagulation with critical INRs and an age- and gender-matched control group…
Comparison
Vitamin K therapy vs Conservative management
Design
Cohort
Authors
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Conservative management may suffice for outpatient INR ≥6.0; leaves open whether randomized trials will confirm equivalence to vitamin K.
Case-Control
No
Does vitamin K therapy improve clinical outcomes compared to conservative management in outpatients with critical INRs ≥ 6.0?
Conservative management of critically high INR values (≥ 6.0) appears to be as efficacious as intervention with vitamin K therapy in outpatients.
Brigden et al. (1998) conducted a case-control in Excessive oral anticoagulation (INR ≥ 6.0). Vitamin K therapy vs. Conservative management was evaluated on Clinical outcome. High-INR patients frequently had drug interactions or compliance issues; conservative management of INR ≥6.0 was as efficacious as vitamin K therapy with no difference in clinical outcomes.
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