January 1, 2009Thrombosis and Haemostasis
Subtherapeutic oral anticoagulant therapy: Frequency and risk factors
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Why the study?
What are the frequency and risk factors for subtherapeutic INRs in patients stably treated with oral anticoagulants?
Population
7,419 patients from a Dutch anticoagulation clinic who started a first treatment with oral anticoagulants…
Comparison
Oral anticoagulant therapy vs Internal comparisons
Design
Cohort
Follow-up
median time to a first low INR was 40 weeks
Authors
Discussion
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Member takes
Implication
May warrant closer INR monitoring with acenocoumarol; leaves open effects on outcomes in observational data.
Structured PICO
What are the frequency and risk factors for subtherapeutic INRs in patients stably treated with oral anticoagulants?
P
Population
7,419 patients from a Dutch anticoagulation clinic who started a first treatment with oral anticoagulants between January 2000 and December 2005 and were stably anticoagulated (4 consecutive INRs in the therapeutic range).
I
Intervention
Oral anticoagulant therapy (acenocoumarol or phenprocoumon)
C
Comparator
Internal comparisons (e.g., phenprocoumon vs acenocoumarol, low vs high therapeutic range)
O
Outcome
Cumulative incidence of subtherapeutic international normalised ratios (INRs) and identification of risk factorssurrogate
In stably anticoagulated patients, subtherapeutic INRs are common and are significantly associated with the use of acenocoumarol, higher therapeutic range targets, and prophylactic indications.
Cite This Study
ROMBOUTS et al. (2009) studied this question.
Topics
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