Key result
Among patients receiving warfarin, women had an increased incidence of low INR compared with men (IRR 1.44; P<0.001), and 21.8% of thromboembolic events occurred during periods of low INR.
Cohort (n=4,489)
Yes
Relative Risk: 1.44
p-value: p=<0.001
Subtherapeutic anticoagulation is common in community practice, particularly among women and VTE patients, and accounts for more than 1 in 5 thromboembolic events.
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Women on warfarin face more frequent low-INR periods tied to >20% of events; leaves open whether sex-specific monitoring reduces thromboembolism risk.
Rose et al. (2009) conducted a cohort in Anticoagulation (n=4,489). Female sex vs. Male sex was evaluated on Incidence of low INR (≤1.5) (IRR 1.44, p=<0.001). Among patients receiving warfarin, women had an increased incidence of low INR compared with men (IRR 1.44; P<0.001), and 21.8% of thromboembolic events occurred during periods of low INR.
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